DNA from Saliva

    Traditional DNA collection methods such as blood extraction are painful for the donor and can limit the number of donors that are willing to participate in an epidemiological study or a clinical trial. As clinicians look for methods to grow their business or improve patient care, or as investigators look for ways to increase donor compliance, it is imperative that non-invasive specimen collection be a feasible and effective alternative.
The most effective, non-invasive source of DNA is saliva. DNA in saliva comes from buccal epithelial cells and white blood cells found in the mouth.

    The Oragene? DNA Self-Collection Kit is designed to enable researchers and clinicians to collect reliable saliva samples. Unlike other oral collection methods, Oragene?DNA yields high-quality, high-quantity DNA from a small saliva sample. Oragene?DNA is optimized to preserve and stabilize saliva samples for long term storage at room temperature without DNA degradation. DNA from Oragene?DNA is equivalent to DNA from blood.

    DNA Genotek has collaborated with vendors of downstream technologies that rely on high-quality DNA for analysis. Learn more about how DNA from Oragene?DNA/saliva samples compares to DNA from blood for sensitive downstream applications:
Saliva DNA that is extracted with Oragene?DNA performs equivalent to or better than blood extracted DNA when used in the Affymetrix Targeted Genotyping assay.

    Comprehensive Gene Sequence Analysis from Bloodspot and Saliva DNA (pdf)
    DNA yield from 250 μl of saliva is similar to yield from 1 ml of whole blood, and resulted in similar performance with the Ambry Genetics TTGE and sequencing protocols.The following is a document that discusses alternate forms of DNA Collection.

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